Good manufacturing practices for medicinal products for human use

Good manufacturing practice for immunological veterinary medicinal products.

Good manufacturing practice (GMP) is applied to the manufacture of immunological veterinary medicinal products (IVMPs) in a number of regions around the world. Within the European Union (EU) there are well-established requirements for GMP in the manufacture of IVMPs. Maintaining GMP when producing IVMPs is important because there are particular risks associated with their manufacture. These ris...

Apitherapy Products for Medicinal Use.

For the past 10 years, beekeeping has increased due to a growing awareness of the disappearance of bees since Colony Collapse Disorder. Most of the disappearance of honey bees can be attributed to the use of pesticides. Apitherapy is the science and art of maintaining health with the use of products from the honeybee hive: honey, bee pollen, propolis, royal jelly, and bee venom. We have been be...

Committee for Medicinal Products for Human Use (chmp) Guideline on the Investigation of Manufacturing Processes for Plasma-derived Medicinal Products with Regard to Vcjd Risk

Committee for Medicinal Products for Veterinary Use

5. Thiabendazole and other benzimidazole anthelmintics act by binding strongly to tubulin in the absorptive cells in the gut of parasitic worms. This interferes with the uptake of nutrients and the worms effectively starve to death. The host is less affected as the binding to mammalian tubulin is less strong and is reversible. Another pharmacological study showed that single oral doses of 25 to...

Committee for Medicinal Products for Veterinary Use

2. The Committee for Medicinal Products for Veterinary Use (CVMP) previously considered triclabendazole and agreed a toxicological ADI of 0.0015 mg/kg bw (i.e. 0.09 mg/person) based on the basis of the increased postpartum mortality of the F2 generation in the two-generation rat reproduction study (NOEL equal to 0.15 mg/kg bw/day) using a safety factor of 100. A validated analytical method base...